Anatomical Pathology

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The Anatomical Pathology Department at the University Hospital of Bellvitge is responsible for the Anatomic Pathology studies of the souther area of Hospitalet de Llobregat and El Prat de Llobregat.

It offers a full portfolio of services, with studies of biopsies and samples, cytologies and autopsies, along with a wide range of special, immunohistochemistry and molecular techniques. It also performs cytohaematology and flow cytometry techniques in haematology diseases. It takes part in external quality controls with an extremely high score. Since 2022, the Service has been immersed in the Digipatics project, which is a project to digitize all samples by initiating the use of artificial intelligence tools. The healthcare activity data for the year 2022 is 39,010 studies of biopsies and surgical specimens, 26,257 cytology tests, 69 autopsies, 23,989 molecular techniques and 59,667 immunohistochemistry technique.

The department has recently received the ISO 15189 certificate for laboratories. It is certified for Anatomical Pathology Residency training, and has a Cytology School that provides specific training for Anatomical Pathology and Cytology graduate technicians to provide them with skills to work as a cytotechnician.



Relevant aspects

  • Surgical Pathology (biopsies)
  • Cytopathology
  • Cytohaematology
  • Autopsies
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  • Electron microscopy
  • Undifferentiated neoplasm diagnosis
  • Renal pathology (glomerulopathies, transplantation)
  • Neuromuscular pathology Metabolic diseases
  • Muscular disease enzyme histochemistry
  • Ophthalmic pathology
  • Sentinel lymph node study (breast, head and neck, cervix-vulva cancer, melanoma)
  • Hematopathology
  • Tumor bank (liquid isopentane freezing, storage –80ºC)
  • Construction of Tissue-microarrays of paraffin block samples Hepatic, renal, cardiac transplantation pathology

  • Automated immunohistochemistry (Catalogue of more than 200 primary antibodies)
  • Papillomavirus detection-typing
  • HPV screening (PCR COBAS 4800)
  • Repair genes (Immunohistochemistry MLH1, MSH2, MSH6, PMS2)
  • Nucleic acid extractions (DNA and RNA)
  • OSNA® (Sentinel lymph node in breast cancer)
  • Clonality of lymphoid neoplasms
  • Her2Neu expression-amplification study (Immunohistochemistry, ISH)
  • KIT mutational study
  • PDGFRA mutational study
  • Mutational study of KRAS, NRAS and BRAF
  • CTNNB1 mutational study
  • EGFR mutational study
  • MYD88 mutational study
  • TERT promoter mutational study
  • POLE mutational study
  • FOXL2 mutational study
  • JAK2 mutational study
  • Methylation studies (MLH1, MGMT and BRCA1)
  • CEA and CK20 expression detection
  • GNAQ, GNA11 and SF3B1 mutational study
  • IDH1/IDH2 mutational study
  • Analysis of chromosomal alterations in chromosomes 1p,3,6 and 8 (MLPA)
  • FISH co-deletion 1p/19q
  • FISH ALK - break apart probe (ALK gene rearrangement)
  • FISH BCL2 - break apart probe (BCL2 gene rearrangement)
  • FISH BCL6 - break apart probe (BCL6 gene rearrangement)
  • FISH CCND1 - break apart probe (CCND1 gene rearrangement)
  • FISH EWSR1 - break apart probe (EWSR1 gene rearrangement)
  • FISH isochromosome 12p FISH MDM2 (MDM2 gene amplification)
  • FISH MET (MET gene amplification)
  • FISH MYC - break apart probe (MYC gene rearrangement)
  • FISH ROS1 - break apart probe (ROS1 gene rearrangement)
  • FISH RET - break apart probe (RET gene rearrangement)
  • FISH SS18 - break apart probe (SS18 gen rearrangement)
  • Microsatellite instability (Multiplex-PCR)
  • Next Generation Sequencing assay (NGS) - Customized panel for somatic vascular diseases, histiocytosis, uveal melanoma, tumors of the central nervous system, endometrial cancer and spitz nevus.
  • Next Generation Sequencing Assay (NGS) - TruSight Oncology 500 (TSO500).
  • Next Generation Sequencing Assay (NGS) - Archer™ FusionPlex™ Sarcoma v2,applied to sarcomas.
  • Next Generation Sequencing (NGS) - Oncomine™ Precision Assay GX (OPA).
  • Study of proteins associated with muscular dystrophies (Western-blot)


Lines of research

  • Gynaecological cancer (Xavier Matias-Guiu, August Vidal, Ester Guerra)
  • Breast cancer (Teresa Soler, Anna Petit, Rosario Taco, Isabel Català, Juan Azcarate)
  • Lymphoid and hemotopietic tumors (Fina Climent, Jan Bosch)
  • Cancer of unknown primary (Maria Pané)
  • Head and neck diseases (Montserrat Gomà)
  • Neuro-oncology (Noemí Vidal)
  • Ageing and cancer (Rosa M. Penin)
  • Sarcomas (Xavier Sanjuan)

Main Publications 

  • Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee. FIGO staging of endometrial cancer: 2023. Int J Gynaecol Obstet. 2023 162:383-394
  • Climent F, Nicolae A, de Leval L, Dirnhofer S, Leoncini L, Ondrejka SL, Soma L, Wotherspoon A, Zamo A, Quintanilla-Martinez L, Ng SB. Cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases: emerging concepts, recent advances, and the putative role of clonal hematopoiesis. A report of the 2022 EA4HP/SH lymphoma workshop. Virchows Arch. 2023 483:333-348.
  • Pane Foix M, Calvo DF, Condom I Mundó E, Novo JFS, Serra EM, Benett JRG, Gàllego MG, Viladomat SY, Julià FV, Vidal I Bel A. Clinical relevance of amyloid in prostate samples: a report on 40 patients. Histopathology. 2022 81:363-370.
  • Concin N, Matias-Guiu X, Vergote I, Cibula D, Mirza MR, Marnitz S, Ledermann J, Bosse T, Chargari C, Fagotti A, Fotopoulou C, Gonzalez Martin A, Lax S, Lorusso D, Marth C, Morice P, Nout RA, O'Donnell D, Querleu D, Raspollini MR, Sehouli J, Sturdza A, Taylor A, Westermann A, Wimberger P, Colombo N, Planchamp F, Creutzberg CL. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer. 2021 31:12-39.
  • Canet-Hermida J, Marín F, Dorca E, Dueñas N, Costas L, Salinas M, Velasco À, Peremiquel-Trillas P, Paytubi S, Ponce J, Fernández S, Martínez JM, Cárdenas L, Taltavull A, Alemany L, Meléndez C, Oliveras G, Vidal A, Capellá G, López-Bonet E, Brunet J, Matias-Guiu X, Pineda M. Highly Sensitive Microsatellite Instability and Immunohistochemistry Assessment in Endometrial Aspirates as a Tool for Cancer Risk Individualization in Lynch Syndrome. Mod Pathol. 2023 36:100158


Degree Education

  • The Departmental professors provide education to 4th Year Medicine Graduates. (Subject: (Anatomical pathology) There is a 4-year Training Programme in the Anatomical Pathology Speciality: Total 8 Residents. Two Residents per year.

Master’s degrees and accredited courses

  • School of Cytology Course: Theory-practical course lasting 1000 hours that provides skills to work as a cytotechnician, using integration into the Cytodiagnosis Section team as its main tool.          

    -Requirements: Anatomical Pathology and Cytology Graduate technicians.        

    -No. of students: 6 per year.          

    -Period: from September to June.          

    -For more information:

  • HUB residency